Failure is only opportunity to begin again, this time more intelligently. -Henry Ford
World is a movie of ups and downs, we all are its main characters trying to make our way up to the top.
Only thing which makes the difference is our attitude, that do we push forward to overcome problems or just simply give up.
Never give up doesn't mean to keep doing same thing in same way what we need is to analyze and be smart enough to change when needed.
A real life example of the physi. Of never give up is " Japan " a country which has faced nuclear bombings and still face tsunami and earthquakes from time to time. But still it bounce back.
Your life is in your hand you are its director, give it an ending you like. Just have courage and stand up to the problems.
One thing you need is " never give up".